![]() ![]() You should avoid exposure to direct external heat sources while wearing fentanyl transdermal. Physicians can adjust the strength of a patch until a patient has adequate pain relief. Ensure that you are using the correct dosage. There are different strengths of patches, all designed to release a different amount of fentanyl per hour. Every 3 days, it will need to be replaced. The patch will continue to work for 72 hours (3 days). The first time a patch is applied, it takes about 12-24 hours for a patient to begin having pain relief. However, it is designed to be released slowly and at a constant, steady rate. When a patch is applied to a patient, it begins releasing the fentanyl immediately.
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